984 research outputs found
Statistics of photodissociation spectra: nonuniversal properties
We consider the two-point correlation function of the photodissociation cross
section in molecules where the fragmentation process is indirect, passing
through resonances above the dissociation threshold. In the limit of
overlapping resonances, a formula is derived, relating this correlation
function to the behavior of the corresponding classical system. It is shown
that nonuniversal features of the two-point correlation function may have
significant experimental manifestations.Comment: 4 pages, 1 figur
Edge effects in graphene nanostructures: II. Semiclassical theory of spectral fluctuations and quantum transport
We investigate the effect of different edge types on the statistical
properties of both the energy spectrum of closed graphene billiards and the
conductance of open graphene cavities in the semiclassical limit. To this end,
we use the semiclassical Green's function for ballistic graphene flakes that we
have derived in Reference 1. First we study the spectral two point correlation
function, or more precisely its Fourier transform the spectral form factor,
starting from the graphene version of Gutzwiller's trace formula for the
oscillating part of the density of states. We calculate the two leading order
contributions to the spectral form factor, paying particular attention to the
influence of the edge characteristics of the system. Then we consider transport
properties of open graphene cavities. We derive generic analytical expressions
for the classical conductance, the weak localization correction, the size of
the universal conductance fluctuations and the shot noise power of a ballistic
graphene cavity. Again we focus on the effects of the edge structure. For both,
the conductance and the spectral form factor, we find that edge induced
pseudospin interference affects the results significantly. In particular
intervalley coupling mediated through scattering from armchair edges is the key
mechanism that governs the coherent quantum interference effects in ballistic
graphene cavities
Point perturbations of circle billiards
The spectral statistics of the circular billiard with a point-scatterer is
investigated. In the semiclassical limit, the spectrum is demonstrated to be
composed of two uncorrelated level sequences. The first corresponds to states
for which the scatterer is located in the classically forbidden region and its
energy levels are not affected by the scatterer in the semiclassical limit
while the second sequence contains the levels which are affected by the
point-scatterer. The nearest neighbor spacing distribution which results from
the superposition of these sequences is calculated analytically within some
approximation and good agreement with the distribution that was computed
numerically is found.Comment: 9 pages, 2 figure
Periodic orbit analysis of an elastodynamic resonator using shape deformation
We report the first definitive experimental observation of periodic orbits
(POs) in the spectral properties of an elastodynamic system. The Fourier
transform of the density of flexural modes show peaks that correspond to stable
and unstable POs of a clover shaped quartz plate. We change the shape of the
plate and find that the peaks corresponding to the POs that hit only the
unperturbed sides are unchanged proving the correspondence. However, an exact
match to the length of the main POs could be made only after a small rescaling
of the experimental results. Statistical analysis of the level dynamics also
shows the effect of the stable POs.Comment: submitted to Europhysics Letter
Symmetry Decomposition of Chaotic Dynamics
Discrete symmetries of dynamical flows give rise to relations between
periodic orbits, reduce the dynamics to a fundamental domain, and lead to
factorizations of zeta functions. These factorizations in turn reduce the labor
and improve the convergence of cycle expansions for classical and quantum
spectra associated with the flow. In this paper the general formalism is
developed, with the -disk pinball model used as a concrete example and a
series of physically interesting cases worked out in detail.Comment: CYCLER Paper 93mar01
Usage personnel de pratiques relevant des médecines douces ou alternatives parmi les médecins suisses
L'importance de l'utilisation pour des besoins personnels de pratiques relevant des médecines douces ou alternatives parmi les médecins est très mal connue. Elle pourrait avoir plusieurs implications notamment par rapport à l'effort actuel de promotion de pratiques médicales fondées sur des preuves d'efficacité (Evidence-based medicine, EBM). [Auteurs]]]>
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2022-05-07T01:30:01Z
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PAX5 activates the transcription of the human telomerase reverse transcriptase gene in B cells.
info:doi:10.1002/path.2620
info:eu-repo/semantics/altIdentifier/doi/10.1002/path.2620
info:eu-repo/semantics/altIdentifier/pmid/19806612
Bougel, Stephanie
Renaud, Stephanie
Braunschweig, Richard
Loukinov, Dmitri
Morse Herbert C. III,
Bosman Fred, T.
Lobanenkov, Victor
Benhattar, Jean
info:eu-repo/semantics/article
article
2010
Journal of Pathology, vol. 220, no. 1, pp. 87-96
info:eu-repo/semantics/altIdentifier/pissn/1096-9896[electronic]
<![CDATA[Telomerase is an RNA-dependent DNA polymerase that synthesizes telomeric DNA. Its activity is not detectable in most somatic cells but it is reactivated during tumorigenesis. In most cancers, the combination of hTERT hypermethylation and hypomethylation of a short promoter region is permissive for low-level hTERT transcription. Activated and malignant lymphocytes express high telomerase activity, through a mechanism that seems methylation-independent. The aim of this study was to determine which mechanism is involved in the enhanced expression of hTERT in lymphoid cells. Our data confirm that in B cells, some T cell lymphomas and non-neoplastic lymph nodes, the hTERT promoter is unmethylated. Binding sites for the B cell-specific transcription factor PAX5 were identified downstream of the ATG translational start site through EMSA and ChIP experiments. ChIP assays indicated that the transcriptional activation of hTERT by PAX5 does not involve repression of CTCF binding. In a B cell lymphoma cell line, siRNA-induced knockdown of PAX5 expression repressed hTERT transcription. Moreover, ectopic expression of PAX5 in a telomerase-negative normal fibroblast cell line was found to be sufficient to activate hTERT expression. These data show that activation of hTERT in telomerase-positive B cells is due to a methylation-independent mechanism in which PAX5 plays an important role
Semiclassical form factor for chaotic systems with spin 1/2
We study the properties of the two-point spectral form factor for classically
chaotic systems with spin 1/2 in the semiclassical limit, with a suitable
semiclassical trace formula as our principal tool. To this end we introduce a
regularized form factor and discuss the limit in which the so-called diagonal
approximation can be recovered. The incorporation of the spin contribution to
the trace formula requires an appropriate variant of the equidistribution
principle of long periodic orbits as well as the notion of a skew product of
the classical translational and spin dynamics. Provided this skew product is
mixing, we show that generically the diagonal approximation of the form factor
coincides with the respective predictions from random matrix theory.Comment: 20 pages, no figure
Separation of variables for the classical and quantum Neumann model
The method of separation of variables is shown to apply to both the classical
and quantum Neumann model. In the classical case this nicely yields the
linearization of the flow on the Jacobian of the spectral curve. In the quantum
case the Schr\"odinger equation separates into one--dimensional equations
belonging to the class of generalized Lam\'e differential equations.Comment: 16 page
Fractal analysis for sets of non-differentiability of Minkowski's question mark function
In this paper we study various fractal geometric aspects of the Minkowski
question mark function We show that the unit interval can be written as
the union of the three sets ,
, and does
not exist and The main result is that the Hausdorff
dimensions of these sets are related in the following way.
Here, refers to the level set of the
Stern-Brocot multifractal decomposition at the topological entropy
of the Farey map and
denotes the Hausdorff dimension of the measure of maximal entropy of the
dynamical system associated with The proofs rely partially on the
multifractal formalism for Stern-Brocot intervals and give non-trivial
applications of this formalism.Comment: 22 pages, 2 figure
Optimization of Gutzwiller Wavefunctions in Quantum Monte Carlo
Gutzwiller functions are popular variational wavefunctions for correlated
electrons in Hubbard models. Following the variational principle, we are
interested in the Gutzwiller parameters that minimize e.g. the expectation
value of the energy. Rewriting the expectation value as a rational function in
the Gutzwiller parameters, we find a very efficient way for performing that
minimization. The method can be used to optimize general Gutzwiller-type
wavefunctions both, in variational and in fixed-node diffusion Monte Carlo.Comment: 9 pages RevTeX with 10 eps figure
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